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The good news is that the racers should all be parking downtown, and not near the Cathedral.
The half marathon starts and finishes downtown; the 5K racers will be shuttled to their start in Hillcrest (at Dove and Washington) at 7am, and will finish downtown.
The bad news is that there will be substantial numbers of road closures, as both the 5K and half marathon come through Hillcrest and end with a long run down 6th Ave. The map is here (or click on the image). Roads will close starting around 5.45 and will not reopen till 10.30 or later.
Access to the Cathedral from North Park, Fashion Valley, and other points north, east , and south will be complicated as parts of Washington, University, part of 5th and most of 6th will be closed. There will be runners coming down 6th Ave in waves between 7.15 and 11.15-ish.
While access from I-5 up Laurel St, or up 1st St, should be open, expect heavy traffic due to the detours.
More race information can be found here.
List of road closures here.