Here's what you need to know.
Saturday: the 5K goes along 6th and the parallel road Balboa Ave, in the Park. It steps off at 7am. Most runners will be done by 7.30ish, and certainly by 8am. If you are coming to the ordination at 10am, there should be little residual traffic. Most streets reopen to traffic at 9am and to parking at 9.30. Map here. Road closures list here.
Sunday: the races start in our neighborhood at 6.15 am and finish downtown. Dean Penny and other stalwarts will stand and bless the runners. Most (but not all) runners will probably park near the finish and take shuttle up to the start. The half marathon (13.1mi) will go through North Park. The marathon (26.2 mii) weaves from the park to Mission Bay and then comes back through Mission Valley, SR163, and the park. This will affect 163 northbound, and many surface streets, many of which will not reopen until the afternoon. Map here.
THere is an extensive list of road closures here.
General notes: Northbound 163 will be shut along with ramps; southbound will be open and able to exit to Washington West. I-5 North and South will have many ramp closures from Sea World to Downtown. Laurel Street and Washington Street will probably be blocked at India until about 9 or 9.15 am. Access from North Park will be complicated, but some roads will start to reopen around 9.
Here's a handy on-line tool to look at closures. It suggests:
Banker's Hill/Park West Alternate Access: 5:00 AM - 8:15 AMOr if you want to come in from the north through Mission Hills/Hillcrest,
Inbound: From I-5 south, exit towards Front/2nd Ave. Veer left to 2nd Ave. Turn left on 3rd Ave to enter area
Inbound: Use southbound SR-163. Exit to westbound Washington.Which ever way you come, expect lots of traffic because of the detours, so leave extra time.